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Evaluation of the diagnostic performance of recombinant antigen B1 for detection of cystic echinococcosis using lateral flow dipstick test

Noordin, R. and Khanbabaie, S. and Hafiznur Yunus, M. and Marti, H. and Nickel, B. and Fasihi Harandi, M. and Nasibi, S.. (2020) Evaluation of the diagnostic performance of recombinant antigen B1 for detection of cystic echinococcosis using lateral flow dipstick test. Iran J Parasitol, 15 (3). pp. 290-298.

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Official URL: https://edoc.unibas.ch/91203/

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Abstract

Background; : Human echinococcosis is a neglected zoonotic disease distributed worldwide. It comprises cystic and alveolar forms, the former being the more prevalent disease. Imaging techniques are the first choice for diagnosis of cystic echinococcosis and serology is used as an additional diagnostic technique in doubtful cases or as the sole test in low-resource settings. Rapid diagnostic tests are useful and convenient for immunodiagnosis of cystic echinococcosis in endemic areas, where medical facilities often struggle with limited resources.; Methods:; Recently, we have developed Hyd Rapidtm, an IgG4 lateral flow dipstick test using recombinant antigen B1 for detection of cystic echinococcosis. This study was performed between 2016 until 2018 at the Institute for Research in Molecular Medicine, Universiti Sains Malaysia. The diagnostic performance of Hyd Rapidtm was tested in-house and at two international laboratories in Switzerland and Iran.; Results:; The overall diagnostic sensitivity for detection of cystic and alveolar echinococcosis was 95% (56/59). Meanwhile, the diagnostic specificity, with and without exclusion of cysticercosis and fascioliasis, was 100% (n=48) and 88% (63/72), respectively.; Conclusion:; Hyd Rapidtm detected cystic echinococcosis as well as probable cases of alveolar echinococcosis. Therefore, Hyd Rapidtm showed good potential as a serological tool for echinococcosis, and merits further evaluation.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Diagnostic (Nickel)
UniBasel Contributors:Marti, Hanspeter and Nickel, Beatrice
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Dec 2022 09:08
Deposited On:29 Dec 2022 09:08

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