Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

Moitra, S. and Carsin, A. E. and Abramson, M. J. and Accordini, S. and Amaral, A. F. S. and Anto, J. and Bono, R. and Casas Ruiz, L. and Cerveri, I. and Chatzi, L. and Demoly, P. and Dorado-Arenas, S. and Forsberg, B. and Gilliland, F. and Gislason, T. and Gullón, J. A. and Heinrich, J. and Holm, M. and Janson, C. and Jogi, R. and Gómez Real, F. and Jarvis, D. and Leynaert, B. and Nowak, D. and Probst-Hensch, N. and Sánchez-Ramos, J. L. and Raherison-Semjen, C. and Siroux, V. and Guerra, S. and Kogevinas, M. and Garcia-Aymerich, J.. (2022) Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS. Thorax. In Press.

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Official URL: https://edoc.unibas.ch/90959/

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INTRODUCTION: Obesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults. METHODS: We used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index>/=30 kg/m(2)) individuals at visit t. The relative risk (RR) of obesity at t+1 associated with asthma at t was estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity. RESULTS: We included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II-III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in </=20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association. CONCLUSION: This is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch)
UniBasel Contributors:Probst-Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Dec 2022 16:10
Deposited On:27 Dec 2022 16:10

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