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Mental distress and health-related quality of life in gambiense human African trypanosomiasis: a case-control study in the Democratic Republic of Congo

Mudji, J. and Ackam, N. and Amoako, Y. A. and Madinga, B. and Mumbere, P. and Agbanyo, A. and Blum, J. and Phillips, R. O. and Molyneux, D. H.. (2022) Mental distress and health-related quality of life in gambiense human African trypanosomiasis: a case-control study in the Democratic Republic of Congo. Trans R Soc Trop Med Hyg, 116 (11). pp. 1022-1031.

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Official URL: https://edoc.unibas.ch/90697/

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Abstract

BACKGROUND: The extent to which neuropsychiatric sequelae affects the mental health status and quality of life of former gambiense human African trypanosomiasis (gHAT) patients is not known. METHODS: We assessed anxiety, depression and health-related quality of life (HRQoL) in 93 patients and their age- and sex-matched controls using the Hospital Anxiety and Depression Scale, Becks Depression Inventory and the 36-item Short Form Health Survey in structured interviews in the Vanga health zone in the Democratic Republic of Congo. Data were analysed using Stata version 14.0. The degree of association between neurologic sequelae and mental distress was evaluated using the Student's t-test and chi2 or Fisher's exact tests, where appropriate, with a p-value <0.05 deemed to be statistically significant. RESULTS: We found that neurological sequelae persisted in former patients at least 15 y after treatment. Depression (p<0.001) and anxiety (p=0.001) were significantly higher in former patients with neurologic sequelae. The mean quality-of-life (QoL) scores were significantly lower for patients than in controls in the physical, emotional and mental health domains. CONCLUSIONS: The presence of neurological sequelae leads to mental distress and a diminished QoL in former gHAT patients. Minimising neurologic sequelae and incorporating psychosocial interventions should be essential management goals for gHAT.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Directorate (DIR) > Medical Services (K├╝nzli/Neumayr)
UniBasel Contributors:Blum, Johannes A.
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1878-3503 (Electronic)0035-9203 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Dec 2022 13:00
Deposited On:27 Dec 2022 13:00

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