Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study

Masselot, P. and Sera, F. and Schneider, R. and Kan, H. and Lavigne, E. and Stafoggia, M. and Tobias, A. and Chen, H. and Burnett, R. T. and Schwartz, J. and Zanobetti, A. and Bell, M. L. and Chen, B. Y. and Leon Guo, Y. L. and Ragettli, M. S. and Vicedo-Cabrera, A. M. and Astrom, C. and Forsberg, B. and Iniguez, C. and Garland, R. M. and Scovronick, N. and Madureira, J. and Nunes, B. and De la Cruz Valencia, C. and Hurtado Diaz, M. and Honda, Y. and Hashizume, M. and Fook Cheng Ng, C. and Samoli, E. and Katsouyanni, K. and Schneider, A. and Breitner, S. and Ryti, N. R. I. and Jaakkola, J. J. K. and Maasikmets, M. and Orru, H. and Guo, Y. and Valdes Ortega, N. and Matus Correa, P. and Tong, S. and Gasparrini, A.. (2022) Differential mortality risks associated with PM2.5 components: a multi-country, multi-city study. Epidemiology, 33 (2). pp. 167-175.

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Official URL: https://edoc.unibas.ch/90642/

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BACKGROUND: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. METHODS: We applied a two-stage analysis on data collected from 210 locations in 16 countries. In the first stage, we estimated location-specific relative risks (RR) for mortality associated with daily total PM2.5 through time series regression analysis. We then pooled these estimates in a meta-regression model that included city-specific logratio-transformed proportions of seven PM2.5 components as well as meta-predictors derived from city-specific socio-economic and environmental indicators. RESULTS: We found associations between RR and several PM2.5 components. Increasing the ammonium (NH4+) proportion from 1% to 22%, while keeping a relative average proportion of other components, increased the RR from 1.0063 (95%CI: 1.0030-1.0097) to 1.0102 (95%CI:1.0070-1.0135). Conversely, an increase in nitrate (NO3-) from 1% to 71% resulted in a reduced RR, from 1.0100 (95%CI: 1.0067-1.0133) to 1.0037 (95%CI: 0.9998- 1.0077). Differences in composition explained a substantial part of the heterogeneity in PM2.5 risk. CONCLUSIONS: These findings contribute to the identification of more hazardous emission sources. Further work is needed to understand the health impacts of PM2.5 components and sources given the overlapping sources and correlations among many components.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli)
UniBasel Contributors:Ragettli, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Dec 2022 12:33
Deposited On:27 Dec 2022 12:33

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