Coarse particulate air pollution and daily mortality: a global study in 205 cities

Liu, C. and Cai, J. and Chen, R. and Sera, F. and Guo, Y. and Tong, S. and Li, S. and Lavigne, E. and Correa, P. M. and Ortega, N. V. and Orru, H. and Maasikmets, M. and Jaakkola, J. J. K. and Ryti, N. and Breitner, S. and Schneider, A. and Katsouyanni, K. and Samoli, E. and Hashizume, M. and Honda, Y. and Ng, C. F. S. and Diaz, M. H. and Valencia, C. C. and Rao, S. and Palomares, A. D. and Silva, S. P. D. and Madureira, J. and Holobâc, I. H. and Fratianni, S. and Scovronick, N. and Garland, R. M. and Tobias, A. and Íñiguez, C. and Forsberg, B. and Åström, C. and Vicedo-Cabrera, A. M. and Ragettli, M. S. and Guo, Y. L. and Pan, S. C. and Milojevic, A. and Bell, M. L. and Zanobetti, A. and Schwartz, J. and Gasparrini, A. and Kan, H.. (2022) Coarse particulate air pollution and daily mortality: a global study in 205 cities. Am J Respir Crit Care Med, 206 (8). pp. 999-1007.

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Official URL: https://edoc.unibas.ch/90620/

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RATIONALE: The associations between ambient coarse particulate matter (PM2.5-10) and daily mortality is not fully understood at a global scale. OBJECTIVES: To evaluate the short-term associations between PM2.5-10 and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide. METHODS: We collected daily mortality (total, cardiovascular, respiratory) and air pollution data from 205 cities in 20 countries/regions. Concentrations of PM2.5-10 were computed as the difference between inhalable and fine particulate matter. A two-stage time-series analytic approach was applied, with over-dispersed generalized linear models and multilevel meta-analysis. We fitted two-pollutant models to test the independent effect of PM2.5-10 from co-pollutants (fine particulate matter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide). Exposure-response relationship curves were pooled and regional analyses were conducted. MEASUREMENTS AND MAIN RESULTS: A 10 mug/m3 increase in PM2.5-10 concentration on lag 0-1 day was associated with increments of 0.51% (95% confidence interval [CI]: 0.18%, 0.84%), 0.43% (95%CI: 0.15%, 0.71%) and 0.41% (95%CI: 0.06%, 0.77%) in total, cardiovascular, and respiratory mortality, respectively. The associations varied by country and region. These associations were robust to adjustment by all co-pollutants in two-pollutant models, especially for PM2.5. The exposure-response curves for total, cardiovascular, and respiratory mortality were positive, with steeper slopes at lower exposure ranges and without discernible thresholds. CONCLUSIONS: This study provides novel global evidence on the robust and independent associations between short-term exposure to ambient PM2.5-10 and total, cardiovascular and respiratory mortality, suggesting the need to establish a unique guideline or regulatory limit for daily concentrations of PM2.5-10.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli)
UniBasel Contributors:Ragettli, Martina
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1535-4970 (Electronic)1073-449X (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Dec 2022 11:14
Deposited On:27 Dec 2022 11:14

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