Hebestreit, H. and Kriemler, S. and Schindler, C. and Stein, L. and Karila, C. and Urquhart, D. S. and Orenstein, D. M. and Lands, L. C. and Schaeff, J. and Eber, E. and Radtke, T. and Activate-CF Study Working Group, . (2022) Effects of a partially supervised conditioning program in cystic fibrosis: an International Multicenter, Randomized Controlled Trial (ACTIVATE-CF). Am J Respir Crit Care Med, 205 (3). pp. 330-339.
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Official URL: https://edoc.unibas.ch/90532/
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Abstract
Rationale: The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear. Objectives: To evaluate effects of a 12-month partially supervised PA intervention using motivational feedback. Methods: In a parallel-arm multicenter randomized controlled trial (ACTIVATE-CF), relatively inactive patients aged at least 12 years were randomly assigned (1:1 ratio) to an intervention group or control group. The intervention group consented to add 3 hours of vigorous PA per week, whereas the control group was asked not to change their PA behavior. Primary endpoint was change in percent predicted FEV1 (DeltaFEV1) at 6 months. Secondary endpoints included PA, exercise capacity, exercise motives, time to first exacerbation and exacerbation rates, quality of life, anxiety, depression, stress, and blood glucose control. Data were analyzed using mixed linear models. Measurements and Main Results: A total of 117 patients (40% of target sample size) were randomized to an intervention (n = 60) or control group (n = 57). After 6 months, DeltaFEV1 was significantly higher in the control group compared with the intervention group (2.70% predicted [95% confidence interval, 0.13-5.26]; P = 0.04). The intervention group reported increased vigorous PA compared with the control group at each study visit, had higher exercise capacity at 6 and 12 months, and higher PA at 12 months. No effects were seen in other secondary outcomes. Conclusions: ACTIVATE-CF increased vigorous PA and exercise capacity, with effects carried over for the subsequent 6 months, but resulted in better FEV1 in the control group.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics Frequentist Modelling (Kwiatkowski) |
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UniBasel Contributors: | Schindler, Christian |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
ISSN: | 1535-4970 (Electronic)1073-449X (Linking) |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 27 Dec 2022 09:39 |
Deposited On: | 27 Dec 2022 09:39 |
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