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Kyasanur forest disease: state-of-the-art review

Gupta, N. and Wilson, W. and Neumayr, A. and Saravu, K.. (2022) Kyasanur forest disease: state-of-the-art review. QJM, 115 (6). pp. 351-358.

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Official URL: https://edoc.unibas.ch/90523/

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Abstract

Kyasanur Forest Disease (KFD) virus is a flavivirus that can be transmitted to humans from monkeys or other mammals through hard ticks (Haemaphysalis spinigera). The disease is endemic to sixteen districts in five states of Southern India and is reported in the dry season, most commonly in humans travelling to the forests in these areas. The aim of this systematic review is to raise awareness of the clinical and laboratory manifestation of KFD among physicians and travel medicine practitioners. A total of 153 articles were screened of which sixteen articles that met the inclusion and exclusion criteria were included for qualitative analysis. KFD is an acute haemorrhagic fever with a biphasic component in some individuals. The second phase is usually marked by neurological symptoms. Leukopenia, thrombocytopenia and elevated transaminases are the hallmarks of the first phase of KFD. The diagnostic modality of choice in the first few days of illness is polymerase chain reaction assay while serology is used in the late phase. In the absence of a specific antiviral treatment, the clinical management of patients is limited to supportive care. Avoidance of exposure and vaccination is recommended to prevent this infection.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Directorate (DIR) > Medical Services (K├╝nzli/Neumayr)
UniBasel Contributors:Neumayr, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1460-2725
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Dec 2022 09:31
Deposited On:27 Dec 2022 09:31

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