Harmonization of human biomonitoring studies in Europe: characteristics of the HBM4EU-aligned studies participants

Gilles, L. and Govarts, E. and Rodriguez Martin, L. and Andersson, A. M. and Appenzeller, B. M. R. and Barbone, F. and Castaño, A. and Coertjens, D. and Den Hond, E. and Dzhedzheia, V. and Er�en, I. and López, M. E. and Fábelová, L. and Fillol, C. and Franken, C. and Frederiksen, H. and Gabriel, C. and Haug, L. S. and Horvat, M. and Halldórsson, T. I. and Janasik, B. and Holcer, N. J. and Kakucs, R. and Karakitsios, S. and Katsonouri, A. and Klanova, J. and Kold-Jensen, T. and Kolossa-Gehring, M. and Konstantinou, C. and Koponen, J. and Lignell, S. and Lindroos, A. K. and Makris, K. C. and Mazej, D. and Morrens, B. and Murínová, L. P. and Namorado, S. and Pedraza-Diaz, S. and Peisker, J. and Probst-Hensch, N. and Rambaud, L. and Rosolen, V. and Rucic, E. and Rüther, M. and Sarigiannis, D. and Tratnik, J. S. and Standaert, A. and Stewart, L. and Szigeti, T. and Thomsen, C. and Tolonen, H. and Eiríksdóttir, A. and Van Nieuwenhuyse, A. and Verheyen, V. J. and Vlaanderen, J. and Vogel, N. and Wasowicz, W. and Weber, T. and Zock, J. P. and Sepai, O. and Schoeters, G.. (2022) Harmonization of human biomonitoring studies in Europe: characteristics of the HBM4EU-aligned studies participants. Int J Environ Res Public Health, 19 (11). p. 6787.

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Human biomonitoring has become a pivotal tool for supporting chemicals' policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern and to evaluate the success of chemical policies. Europe has launched the ambitious REACH program in 2007 to improve the protection of human health and the environment. In October 2020 the EU commission published its new chemicals strategy for sustainability towards a toxic-free environment. The European Parliament called upon the commission to collect human biomonitoring data to support chemical's risk assessment and risk management. This manuscript describes the organization of the first HBM4EU-aligned studies that obtain comparable human biomonitoring (HBM) data of European citizens to monitor their internal exposure to environmental chemicals. The HBM4EU-aligned studies build on existing HBM capacity in Europe by aligning national or regional HBM studies. The HBM4EU-aligned studies focus on three age groups: children, teenagers, and adults. The participants are recruited between 2014 and 2021 in 11 to 12 primary sampling units that are geographically distributed across Europe. Urine samples are collected in all age groups, and blood samples are collected in children and teenagers. Auxiliary information on socio-demographics, lifestyle, health status, environment, and diet is collected using questionnaires. In total, biological samples from 3137 children aged 6-12 years are collected for the analysis of biomarkers for phthalates, HEXAMOLL((R)) DINCH, and flame retardants. Samples from 2950 teenagers aged 12-18 years are collected for the analysis of biomarkers for phthalates, Hexamoll((R)) DINCH, and per- and polyfluoroalkyl substances (PFASs), and samples from 3522 adults aged 20-39 years are collected for the analysis of cadmium, bisphenols, and metabolites of polyaromatic hydrocarbons (PAHs). The children's group consists of 50.4% boys and 49.5% girls, of which 44.1% live in cities, 29.0% live in towns/suburbs, and 26.8% live in rural areas. The teenagers' group includes 50.6% girls and 49.4% boys, with 37.7% of residents in cities, 31.2% in towns/suburbs, and 30.2% in rural areas. The adult group consists of 52.6% women and 47.4% men, 71.9% live in cities, 14.2% in towns/suburbs, and only 13.4% live in rural areas. The study population approaches the characteristics of the general European population based on age-matched EUROSTAT EU-28, 2017 data; however, individuals who obtained no to lower educational level (ISCED 0-2) are underrepresented. The data on internal human exposure to priority chemicals from this unique cohort will provide a baseline for Europe's strategy towards a non-toxic environment and challenges and recommendations to improve the sampling frame for future EU-wide HBM surveys are discussed.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Exposome Science (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Exposome Science (Probst-Hensch)
UniBasel Contributors:Probst-Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1660-4601 (Electronic)1660-4601 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Dec 2022 16:24
Deposited On:22 Dec 2022 16:24

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