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Medicinal plant preparations administered by botswana traditional health practitioners for treatment of worm infections show anthelmintic activities

Dube, M. and Raphane, B. and Sethebe, B. and Seputhe, N. and Tiroyakgosi, T. and Imming, P. and Häberli, C. and Keiser, J. and Arnold, N. and Andrae-Marobela, K.. (2022) Medicinal plant preparations administered by botswana traditional health practitioners for treatment of worm infections show anthelmintic activities. Plants (Basel), 11 (21). p. 2945.

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Abstract

Schistosomiasis and soil-transmitted helminths are some of the priority neglected tropical diseases (NTDs) targeted for elimination by the World Health Organization (WHO). They are prevalent in Botswana and although Botswana has begun mass drug administration with the hope of eliminating soil-transmitted helminths as a public health problem, the prevalence of schistosomiasis does not meet the threshold required to warrant large-scale interventions. Although Botswana has a modern healthcare system, many people in Botswana rely on traditional medicine to treat worm infections and schistosomiasis. In this study, ten plant species used by traditional health practitioners against worm infections were collected and tested against Ancylostoma ceylanicum (zoonotic hookworm), Heligmosomoides polygyrus (roundworm of rodents), Necator americanus (New World hookworm), Schistosoma mansoni (blood fluke) [adult and newly transformed schistosomula (NTS)], Strongyloides ratti (threadworm) and Trichuris muris (nematode parasite of mice) in vitro. Extracts of two plants, Laphangium luteoalbum and Commiphora pyaracanthoides, displayed promising anthelmintic activity against NTS and adult S. mansoni, respectively. L. luteoalbum displayed 85.4% activity at 1 mug/mL against NTS, while C. pyracanthoides displayed 78.5% activity against adult S. mansoni at 10 mug/mL.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Helminth Drug Development (Keiser)
UniBasel Contributors:Häberli, Cécile and Keiser, Jennifer
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2223-7747 (Print)2223-7747 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:21 Dec 2022 18:39
Deposited On:21 Dec 2022 18:39

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