Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography

Yushchenko, Maksym and Sarracanie, Mathieu and Salameh, Najat. (2022) Fast acquisition of propagating waves in humans with low-field MRI: Toward accessible MR elastography. Science advances, 8 (36). eabo5739.

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Official URL: https://edoc.unibas.ch/89945/

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Most commonly used at clinical magnetic fields (1.5 to 3 T), magnetic resonance elastography (MRE) captures mechanical wave propagation to reconstruct the mechanical properties of soft tissue with MRI. However, in terms of noninvasively assessing disease progression in a broad range of organs (e.g., liver, breast, skeletal muscle, and brain), its accessibility is limited and its robustness is challenged when magnetic susceptibility differences are encountered. Low-field MRE offers an opportunity to overcome these issues, and yet it has never been demonstrated in vivo in humans with magnetic fields <1.5 T mainly because of the long acquisition times required to achieve a sufficient signal-to-noise ratio. Here, we describe a method to accelerate 3D motion-sensitized MR scans at 0.1 T using only 10%; k; -space sampling combined with a high-performance detector and an efficient encoding acquisition strategy. Its application is demonstrated in vivo in the human forearm for a single motion-encoding direction in less than 1 min.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Imaging and Computational Modelling > Adaptable MRI Technology (Salameh)
UniBasel Contributors:Salameh, Najat
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Sep 2022 11:04
Deposited On:24 Sep 2022 11:04

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