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Antiviral death punch by ADP-ribosylating bacterial toxins

Shaidullina, Aisylu and Harms, Alexander. (2022) Antiviral death punch by ADP-ribosylating bacterial toxins. Trends in Microbiology, 30 (10). pp. 920-921.

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Abstract

Toxin-antitoxin systems can defend bacteria against phages by shutting down infected cells, but the links between their molecular mechanisms and biological functions have remained underexplored. LeRoux et al. now show how the DNA-targeting ADP-ribosylation activity of DarTG impairs phage replication but is overcome by dedicated viral inhibitors and evolved tolerance.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal)
05 Faculty of Science > Departement Biozentrum > Infection Biology > Molecular Microbiology (Jenal) > Molecular Microbiology (Harms)
05 Faculty of Science > Departement Biozentrum > Growth & Development > Molecular Microbiology (Jenal) > Molecular Microbiology (Harms)
UniBasel Contributors:Harms, Alexander and Shaidullina, Aisylu
Item Type:Article
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0966-842X
e-ISSN:1878-4380
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:14 Sep 2022 12:24
Deposited On:14 Sep 2022 09:43

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