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Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults

Jongo, S. A. and Urbano, V. and Church, L. W. P. and Olotu, A. and Manock, S. R. and Schindler, T. and Mtoro, A. and Kc, N. and Hamad, A. and Nyakarungu, E. and Mpina, M. and Deal, A. and Bijeri, J. R. and Ondo Mangue, M. E. and Ntutumu Pasialo, B. E. and Nguema, G. N. and Owono, S. N. and Rivas, M. R. and Chemba, M. and Kassim, K. R. and James, E. R. and Stabler, T. and Abebe, Y. and Saverino, E. and Sax, J. and Hosch, S. and Tumbo, A. M. and Gondwe, L. and Segura, J. L. and Falla, C. C. and Phiri, W. P. and Hergott, D. E. B. and Garcia, G. A. and Schwabe, C. and Maas, C. D. and Murshedkar, T. and Billingsley, P. F. and Tanner, M. and Ayekaba, M. O. and Sim, B. K. L. and Daubenberger, C. and Richie, T. L. and Abdulla, S. and Hoffman, S. L.. (2021) Immunogenicity and protective efficacy of radiation-attenuated and chemo-attenuated PfSPZ vaccines in Equatoguinean adults. Am J Trop Med Hyg, 104 (1). pp. 283-293.

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Official URL: https://edoc.unibas.ch/89092/

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Abstract

Plasmodium falciparum sporozoite (PfSPZ) Vaccine (radiation-attenuated, aseptic, purified, cryopreserved PfSPZ) and PfSPZ-CVac (infectious, aseptic, purified, cryopreserved PfSPZ administered to subjects taking weekly chloroquine chemoprophylaxis) have shown vaccine efficacies (VEs) of 100% against homologous controlled human malaria infection (CHMI) in nonimmune adults. Plasmodium falciparum sporozoite-CVac has never been assessed against CHMI in African vaccinees. We assessed the safety, immunogenicity, and VE against homologous CHMI of three doses of 2.7 x 10(6) PfSPZ of PfSPZ Vaccine at 8-week intervals and three doses of 1.0 x 10(5) PfSPZ of PfSPZ-CVac at 4-week intervals with each arm randomized, double-blind, placebo-controlled, and conducted in parallel. There were no differences in solicited adverse events between vaccinees and normal saline controls, or between PfSPZ Vaccine and PfSPZ-CVac recipients during the 6 days after administration of investigational product. However, from days 7-13, PfSPZ-CVac recipients had significantly more AEs, probably because of Pf parasitemia. Antibody responses were 2.9 times higher in PfSPZ Vaccine recipients than PfSPZ-CVac recipients at time of CHMI. Vaccine efficacy at a median of 14 weeks after last PfSPZ-CVac dose was 55% (8 of 13, P = 0.051) and at a median of 15 weeks after last PfSPZ Vaccine dose was 27% (5 of 15, P = 0.32). The higher VE in PfSPZ-CVac recipients of 55% with a 27-fold lower dose was likely a result of later stage parasite maturation in the liver, leading to induction of cellular immunity against a greater quantity and broader array of antigens.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Clinical Immunology (Daubenberger)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither)
UniBasel Contributors:Schindler, Tobias and Mpina, Maximillian and Deal, Anna and Sax, Julian Martin and Hosch, Salome and Tumbo, Anneth and Gondwe, Linda and Daubenberger, Claudia
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1476-1645 (Electronic)0002-9637 (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:20 Dec 2022 10:16
Deposited On:20 Dec 2022 10:16

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