Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions

Dudas, G. and Hong, S. L. and Potter, B. I. and Calvignac-Spencer, S. and Niatou-Singa, F. S. and Tombolomako, T. B. and Fuh-Neba, T. and Vickos, U. and Ulrich, M. and Leendertz, F. H. and Khan, K. and Huber, C. and Watts, A. and Olendraite, I. and Snijder, J. and Wijnant, K. N. and Bonvin, Amjj and Martres, P. and Behillil, S. and Ayouba, A. and Maidadi, M. F. and Djomsi, D. M. and Godwe, C. and Butel, C. and Simaitis, A. and Gabrielaite, M. and Katenaite, M. and Norvilas, R. and Raugaite, L. and Koyaweda, G. W. and Kandou, J. K. and Jonikas, R. and Nasvytiene, I. and Zemeckiene, Z. and Gečys, D. and Tamusauskaite, K. and Norkiene, M. and Vasiliunaite, E. and Timinskas, A. and Alzbutas, G. and Aziza, A. A. and Lusamaki, E. K. and Cigolo, J. M. and Mawete, F. M. and Lofiko, E. L. and Kingebeni, P. M. and Tamfum, J. M. and Belizaire, M. R. D. and Essomba, R. G. and Assoumou, M. C. O. and Mboringong, A. B. and Dieng, A. B. and Juozapaite, D. and Hosch, S. and Obama, J. and Ayekaba, M. O. and Naumovas, D. and Pautienius, A. and Rafaï, C. D. and Vitkauskienė, A. and Ugenskienė, R. and Gedvilaitė, A. and Čere�kevičius, D. and Lesauskaitė, V. and Gri�kevičius, L. and Baele, G.. (2021) Emergence and spread of SARS-CoV-2 lineage B.1.620 with variant of concern-like mutations and deletions. Nat Commun, 12. p. 5769.

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Official URL: https://edoc.unibas.ch/89037/

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Abstract

Distinct SARS-CoV-2 lineages, discovered through various genomic surveillance initiatives, have emerged during the pandemic following unprecedented reductions in worldwide human mobility. We here describe a SARS-CoV-2 lineage - designated B.1.620 - discovered in Lithuania and carrying many mutations and deletions in the spike protein shared with widespread variants of concern (VOCs), including E484K, S477N and deletions HV69Delta, Y144Delta, and LLA241/243Delta. As well as documenting the suite of mutations this lineage carries, we also describe its potential to be resistant to neutralising antibodies, accompanying travel histories for a subset of European cases, evidence of local B.1.620 transmission in Europe with a focus on Lithuania, and significance of its prevalence in Central Africa owing to recent genome sequencing efforts there. We make a case for its likely Central African origin using advanced phylogeographic inference methodologies incorporating recorded travel histories of infected travellers.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Clinical Immunology (Daubenberger)
UniBasel Contributors:	Hosch, Salome
Item Type:	Article, refereed
Article Subtype:	Research Article
ISSN:	2041-1723 (Electronic)2041-1723 (Linking)
Note:	Publication type according to Uni Basel Research Database: Journal article
Language:	English
Related URLs:	Document
Identification Number:	doi: 10.1038/s41467-021-26055-8 pmid: 34599175
edoc DOI:	10.5451/unibas-ep89037
Last Modified:	20 Dec 2022 09:19
Deposited On:	20 Dec 2022 09:19

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