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Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil

Fink, G. and Orlova-Fink, N. and Schindler, T. and Grisi, S. and Ferrer, A. P. S. and Daubenberger, C. and Brentani, A.. (2021) Inactivated trivalent influenza vaccination is associated with lower mortality among patients with COVID-19 in Brazil. BMJ Evid Based Med, 26 (4). pp. 192-193.

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Official URL: https://edoc.unibas.ch/89019/

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Abstract

OBJECTIVE: To estimate associations between trivalent influenza vaccination and COVID-19 mortality as well as severe clinical outcomes among hospitalised patients. DESIGN: Retrospective observational study. SETTING: This study was conducted among hospitalised patients with COVID-19 in Brazil. PARTICIPANTS: We analysed all hospitalised patients with COVID-19 with available vaccination information captured in Brazil's national electronic respiratory infection data system between 1 January 2020 and 23 June 2020. MAIN OUTCOME MEASURES: The primary outcomes were age-specific mortality rates of hospitalised patients with COVID-19 with and without recent inactivated trivalent influenza vaccination. RESULTS: A total of 53 752 clinically confirmed COVID-19 cases were analysed. Controlling for health facility of treatment, comorbidities as well as an extensive range of sociodemographic factors, patients who received a recent influenza vaccine experienced on average 7% lower odds of needing intensive care treatment (95% CI 0.87 to 0.98), 17% lower odds of requiring invasive respiratory support (95% CI 0.77 to 0.88) and 16% lower odds of death (95% CI 0.78 to 0.90). Protective effects were larger when the vaccine was administered after onset of symptoms as well as among younger patients. CONCLUSION: Patients with COVID-19 with recent inactivated influenza vaccination experience significantly better health outcomes than non-vaccinated patients in Brazil. Beneficial off-target effects of influenza vaccination through trained innate immune responses seem plausible and need to be further explored. Large-scale promotion of influenza vaccines seems advisable, especially in populations at high risk for severe COVID-19 disease progression.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Household Economics and Health Systems Research > Epidemiology and Household Economics (Fink)
06 Faculty of Business and Economics > Departement Wirtschaftswissenschaften > Professuren Wirtschaftswissenschaften > Epidemiology and Household Economics (Fink)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Clinical Immunology (Daubenberger)
UniBasel Contributors:Fink, G√ľnther and Orlova-Fink, Nina and Schindler, Tobias and Daubenberger, Claudia
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2515-4478 (Electronic)2515-446X (Linking)
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Dec 2022 15:03
Deposited On:19 Dec 2022 15:03

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