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A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16

Asherson, P. and Zhou, K. and Anney, R. J. L. and Franke, B. and Buitelaar, J. and Ebstein, R. and Gill, M. and Altink, M. and Arnold, R. and Boer, F. and Brookes, K. and Buschgens, C. and Butler, L. and Cambell, D. and Chen, W. and Christiansen, H. and Feldman, L. and Fleischman, K. and Fliers, E. and Howe-Forbes, R. and Goldfarb, A. and Heise, A. and Gabriëls, I. and Johansson, L. and Lubetzki, I. and Marco, R. and Medad, S. and Minderaa, R. and Mulas, F. and Müller, U. and Mulligan, A. and Neale, B. and Rijsdijk, F. and Rabin, K. and Rommelse, N. and Sethna, V. and Sorohan, J. and Uebel, H. and Psychogiou, L. and Weeks, A. and Barrett, R. and Xu, X. and Banaschewski, T. and Sonuga-Barke, E. and Eisenberg, J. and Manor, I. and Miranda, A. and Oades, R. D. and Roeyers, H. and Rothenberger, A. and Sergeant, J. and Steinhausen, H.-C. and Taylor, E. and Thompson, M. and Faraone, S. V.. (2008) A high-density SNP linkage scan with 142 combined subtype ADHD sib pairs identifies linkage regions on chromosomes 9 and 16. Molecular psychiatry, Vol. 13, H. 5. pp. 514-521.

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Official URL: http://edoc.unibas.ch/dok/A5250688

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Abstract

As part of the International Multi-centre ADHD Genetics project we completed an affected sibling pair study of 142 narrowly defined Diagnostic and Statistical Manual of Mental Disorders, fourth edition combined type attention deficit hyperactivity disorder (ADHD) proband-sibling pairs. No linkage was observed on the most established ADHD-linked genomic regions of 5p and 17p. We found suggestive linkage signals on chromosomes 9 and 16, respectively, with the highest multipoint nonparametric linkage signal on chromosome 16q23 at 99 cM (log of the odds, LOD=3.1) overlapping data published from the previous UCLA (University of California, Los Angeles) (LOD<1, approximately 95 cM) and Dutch (LOD<1, approximately 100 cM) studies. The second highest peak in this study was on chromosome 9q22 at 90 cM (LOD=2.13); both the previous UCLA and German studies also found some evidence of linkage at almost the same location (UCLA LOD=1.45 at 93 cM; German LOD=0.68 at 100 cM). The overlap of these two main peaks with previous findings suggests that loci linked to ADHD may lie within these regions. Meta-analysis or reanalysis of the raw data of all the available ADHD linkage scan data may help to clarify whether these represent true linked loci.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publishing Group
ISSN:1359-4184
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:25
Deposited On:22 Mar 2012 13:46

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