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Assembly of a protein "brush" by end-grafting titin fragments to liposomes

Chami, Mohamed and Franke, Barbara and Mayans, Olga and Kreplak, Laurent. (2011) Assembly of a protein "brush" by end-grafting titin fragments to liposomes. Journal of bioscience and bioengineering, 112 (2). pp. 178-179.

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Official URL: https://edoc.unibas.ch/88849/

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Abstract

Titin is a giant filamentous protein of striated muscle composed of >300 immunoglobulin-like domains linked in tandem. Here, we demonstrate that a six-immunoglobulin fragment of titin carrying a poly-histidine tag forms a protein "brush" on liposomes containing metallochelating lipids. These specimens might allow the direct visualization by cryo-EM of frozen hydrated and unstained titin chains with preserved architectural features.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > BioEM Lab (Chami)
UniBasel Contributors:Chami, Mohamed
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1347-4421
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2022 13:42
Deposited On:19 Jul 2022 13:42

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