Towards a Better Understanding of the Epidemiology and Control of Eumycetoma

Hassan, Mahmoud. Towards a Better Understanding of the Epidemiology and Control of Eumycetoma. 2019, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.


Official URL: https://edoc.unibas.ch/88408/

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Eumycetoma, a neglected tropical disease with considerable knowledge gaps. Eumycetoma has shown worldwide pattern of incidence, yet most of the patients are living in the tropics and subtropics and are mostly living in poor communities. Madurella mycetomatis, a fungus which is considered the first in the broad list of fungal pathogens, recently M. mycetomatis was exploited with modern biological techniques which hopefully ended with whole genome sequencing, development of PCR diagnostic tool, and revealing many aspects of the host-parasite interactions.
The aim of this PhD thesis were (i) advance the knowledge on aspects of eumycetoma epidemiology (ii) investigate potential drug targets and active compounds for prospect control and elimination (iii) conduct comparative genomics to answer the questions in (ii) and to search for specific virulence genes that could explain the human invasion by the causative agents.
The list of eumycetoma pathogens featured 130 fully identified species along with 13 partially identified pathogens (genus only), these agents have shown differences in their spatial distribution; some species were of limited distribution including Aspergillus fumigatus and Leptospheria senegalensis, while M. mycetomatis and Madurella grisea have shown worldwide distribution. Comparing the proteomes of eumycetoma fungi to those from famous phytopathogens revealed the potential of adenosine deaminase, chitin synthase, and succinate dehydrogenase to serve as future drug targets against eumycetoma fungal pathogens.
We have also identified myosine related proteins and other set of proteins to have remarkable conservation bias towards eumycetoma fungal pathogens compared to apathogenic species closely related which makes them potential virulence factors.
Advisors:Tanner, Marcel and Mäser, Pascal and Schneiter, Roger
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Malaria Vaccines (Tanner)
UniBasel Contributors:Tanner, Marcel and Mäser, Pascal
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14727
Thesis status:Complete
Number of Pages:VII, 104
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss147274
edoc DOI:
Last Modified:15 Jun 2022 04:30
Deposited On:14 Jun 2022 09:59

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