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The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates

Weis, Karsten and Hondele, Maria. (2022) The Role of DEAD-Box ATPases in Gene Expression and the Regulation of RNA-Protein Condensates. Annual Review of Biochemistry, 91. pp. 197-219.

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Abstract

DEAD-box ATPases constitute a very large protein family present in all cells, often in great abundance. From bacteria to humans, they play critical roles in many aspects of RNA metabolism, and due to their widespread importance in RNA biology, they have been characterized in great detail at both the structural and biochemical levels. DEAD-box proteins function as RNA-dependent ATPases that can unwind short duplexes of RNA, remodel ribonucleoprotein (RNP) complexes, or act as clamps to promote RNP assembly. Yet, it often remains enigmatic how individual DEAD-box proteins mechanistically contribute to specific RNA-processing steps. Here, we review the role of DEAD-box ATPases in the regulation of gene expression and propose that one common function of these enzymes is in the regulation of liquid-liquid phase separation of RNP condensates. Expected final online publication date for the; Annual Review of Biochemistry; , Volume 91 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hondele)
UniBasel Contributors:Hondele, Maria
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Annual Reviews
ISSN:0066-4154
e-ISSN:1545-4509
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:19 Jul 2022 14:33
Deposited On:19 Jul 2022 14:33

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