Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights

Gander, Joséphine and Carrard, Justin and Gallart-Ayala, Hector and Borreggine, Rébecca and Teav, Tony and Infanger, Denis and Colledge, Flora and Streese, Lukas and Wagner, Jonathan and Klenk, Christopher and Nève, Gilles and Knaier, Raphael and Hanssen, Henner and Schmidt-Trucksäss, Arno and Ivanisevic, Julijana. (2021) Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights. Frontiers in cardiovascular medicine, 8. p. 792350.

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Coronary artery disease (CAD) remains the leading cause of death worldwide. Expanding patients' metabolic phenotyping beyond clinical chemistry investigations could lead to earlier recognition of disease onset and better prevention strategies. Additionally, metabolic phenotyping, at the molecular species level, contributes to unravel the roles of metabolites in disease development. In this cross-sectional study, we investigated clinically healthy individuals (; n; = 116, 65% male, 70.8 ± 8.7 years) and patients with CAD (; n; = 54, 91% male, 67.0 ± 11.5 years) of the COmPLETE study. We applied a high-coverage quantitative liquid chromatography-mass spectrometry approach to acquire a comprehensive profile of serum acylcarnitines, free carnitine and branched-chain amino acids (BCAAs), as markers of mitochondrial health and energy homeostasis. Multivariable linear regression analyses, adjusted for confounders, were conducted to assess associations between metabolites and CAD phenotype. In total, 20 short-, medium- and long-chain acylcarnitine species, along with L-carnitine, valine and isoleucine were found to be significantly (adjusted; p; ≤ 0.05) and positively associated with CAD. For 17 acylcarnitine species, associations became stronger as the number of affected coronary arteries increased. This implies that circulating acylcarnitine levels reflect CAD severity and might play a role in future patients' stratification strategies. Altogether, CAD is characterized by elevated serum acylcarnitine and BCAA levels, which indicates mitochondrial imbalance between fatty acid and glucose oxidation.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit
UniBasel Contributors:Wagner, Jonathan and Streese, Lukas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media S.A.
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:30 Apr 2022 13:14
Deposited On:30 Apr 2022 13:14

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