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Global dynamics of microbial communities emerge from local interaction rules

van Vliet, Simon and Hauert, Christoph and Fridberg, Kyle and Ackermann, Martin and Dal Co, Alma. (2022) Global dynamics of microbial communities emerge from local interaction rules. PLoS Computational Biology, 18 (3). e1009877.

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Official URL: https://edoc.unibas.ch/88017/

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Abstract

Most microbes live in spatially structured communities (e.g., biofilms) in which they interact with their neighbors through the local exchange of diffusible molecules. To understand the functioning of these communities, it is essential to uncover how these local interactions shape community-level properties, such as the community composition, spatial arrangement, and growth rate. Here, we present a mathematical framework to derive community-level properties from the molecular mechanisms underlying the cell-cell interactions for systems consisting of two cell types. Our framework consists of two parts: a biophysical model to derive the local interaction rules (i.e. interaction range and strength) from the molecular parameters underlying the cell-cell interactions and a graph based model to derive the equilibrium properties of the community (i.e. composition, spatial arrangement, and growth rate) from these local interaction rules. Our framework shows that key molecular parameters underlying the cell-cell interactions (e.g., the uptake and leakage rates of molecules) determine community-level properties. We apply our model to mutualistic cross-feeding communities and show that spatial structure can be detrimental for these communities. Moreover, our model can qualitatively recapitulate the properties of an experimental microbial community. Our framework can be extended to a variety of systems of two interacting cell types, within and beyond the microbial world, and contributes to our understanding of how community-level properties emerge from microscopic interactions between cells.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher) > Microbial Systems Ecology (van Vliet)
UniBasel Contributors:van Vliet, Simon
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Library of Science
ISSN:1553-734X
e-ISSN:1553-7358
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:09 Mar 2022 12:02
Deposited On:09 Mar 2022 12:02

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