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Age at Time of Kidney Transplantation as a Predictor for Mortality, Graft Loss and Self-Rated Health Status: Results From the Swiss Transplant Cohort Study

Beerli, Nadine and Denhaerynck, Kris and Binet, Isabelle and Dahdal, Suzan and Dickenmann, Michael and Golshayan, Delaviz and Hadaya, Karine and Huynh-Do, Uyen and Schnyder, Aurelia and De Geest, Sabina M. and Mauthner, Oliver. (2022) Age at Time of Kidney Transplantation as a Predictor for Mortality, Graft Loss and Self-Rated Health Status: Results From the Swiss Transplant Cohort Study. Transplant International, 35. p. 10076.

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Abstract

Introduction:; The effect of age on health outcomes in kidney transplantation remains inconclusive. This study aimed to analyze the relationship between age at time of kidney transplantation with mortality, graft loss and self-rated health status in adult kidney transplant recipients.; Methods:; This study used data from the Swiss Transplant Cohort Study and included prospective data of kidney transplant recipients between 2008 and 2017. Time-to-event analysis was performed using Cox' regression analysis, and -in the case of graft loss- competing risk analysis. A random-intercept regression model was applied to analyse self-rated health status.; Results:; We included 2,366 kidney transplant recipients. Age at transplantation linearly predicted mortality. It was also predictive for graft loss, though nonlinearly, showing that recipients aged between 35 and 55 years presented with the lowest risk of experiencing graft loss. No relationship of age with self-rated health status was detected.; Conclusion:; Higher mortality in older recipients complies with data from the general population. The non-linear relationship between age and graft loss and the higher scored self-rated health status at all follow-up time-points compared to the pre-transplant status -regardless of age- highlight that age alone might not be an accurate measure for risk prediction and clinical decision making in kidney transplantation.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Institut für Pflegewissenschaft
UniBasel Contributors:Beerli, Nadine and Denhaerynck, Kris and De Geest, Sabina M. and Mauthner, Oliver
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers
ISSN:0934-0874
e-ISSN:1432-2277
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:23 Mar 2022 16:32
Deposited On:23 Mar 2022 16:32

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