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pH-responsive PDMS-b-PDMAEMA micelles for intracellular anticancer drug delivery

Car, Anja and Baumann, Patric and Duskey, Jason T. and Chami, Mohamed and Bruns, Nico and Meier, Wolfgang. (2014) pH-responsive PDMS-b-PDMAEMA micelles for intracellular anticancer drug delivery. Biomacromolecules, 15 (9). pp. 3235-3245.

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Official URL: https://edoc.unibas.ch/87953/

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Abstract

A series of poly(dimethysiloxane)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMS-b-PDMAEMA) block copolymers were synthesized with atom transfer radical polymerization (ATRP). In aqueous solution the polymers self-assembled into micelles with diameters between 80 and 300 nm, with the ability to encapsulate DOX. The polymer with the shortest PDMAEMA block (5 units) displayed excellent cell viability, while micelles containing longer PDMAEMA block lengths (13 and 22 units) led to increased cytotoxicity. The carriers released DOX in response to a decrease in pH from 7.4 to 5.5. Confocal laser scanning microscopy (CLSM) revealed that nanoparticles were taken up by endocytosis into acidic cell compartments. Furthermore, DOX-loaded nanocarriers exhibited intracellular pH-response as changes in cell morphology and drug release were observed within 24 h.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Engel)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > BioEM Lab (Chami)
UniBasel Contributors:Chami, Mohamed
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
ISSN:1525-7797
e-ISSN:1526-4602
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:08 Mar 2022 11:40
Deposited On:08 Mar 2022 11:40

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