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Sex-specific differences in adverse outcome events among patients with atrial fibrillation

Evers-Dörpfeld, Simone and Aeschbacher, Stefanie and Hennings, Elisa and Eken, Ceylan and Coslovsky, Michael and Rodondi, Nicolas and Beer, Jürg H. and Moschovitis, Giorgio and Ammann, Peter and Kobza, Richard and Ceylan, Selinda and Krempke, Melina and Meyer-Zürn, Christine S. and Moutzouri, Elisavet and Springer, Anne and Sticherling, Christian and Bonati, Leo H. and Osswald, Stefan and Kuehne, Michael and Conen, David and Swiss-AF Investigators, . (2022) Sex-specific differences in adverse outcome events among patients with atrial fibrillation. Heart , 108 (18). pp. 1445-1451.

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Abstract

To assess whether women with atrial fibrillation (AF) have a higher risk of adverse events than men during long-term follow-up since controversial data have been published.; In the context of two very similar observational multicentre cohort studies, we prospectively followed 3894 patients (28% women) with previously documented AF for a median of 4.02 (3.00-5.83) years. The primary outcome was a composite of ischaemic stroke, myocardial infarction and cardiovascular death. Secondary outcomes included the individual components of the composite outcome, hospitalisation for heart failure, major and clinically relevant non-major bleeding, stroke or systemic embolism and non-cardiovascular death.; Mean age was 73.1 years in women vs 70.8 years in men. The incidence of the primary endpoint in women versus men was 2.46 vs 3.24 per 100 patient-years, respectively (adjusted HR (aHR) 0.74, 95% CI 0.58 to 0.94; p=0.01). Women died less frequently from cardiovascular (aHR 0.57, 95% CI 0.41 to 0.78; p<0.001) and non-cardiovascular causes (aHR 0.68, 95% CI 0.47 to 0.98; p=0.04). There were no significant sex-specific differences in stroke (incidence 1.05 vs 1.00; aHR 1.02, 95% CI 0.70 to 1.49, p=0.93), myocardial infarction (incidence 0.67 vs 0.72; aHR 0.98, 95% CI 0.61 to 1.57, p=0.94), major and clinically relevant non-major bleeding (incidence 4.51 vs 4.34; aHR 0.95, 95% CI 0.79 to 1.15, p=0.63) or heart failure hospitalisation (incidence 3.28 vs 3.07; aHR 1.06, 95% CI 0.85 to 1.32, p=0.60).; In this large study of patients with established AF, women had a lower risk of death than men, but there were no sex-specific differences in other adverse outcomes.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie > Kardiologie (Conen)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie > Kardiologie (Conen)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie > Kardiologie Elektrophysiologie (Osswald)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie > Kardiologie Elektrophysiologie (Osswald)
UniBasel Contributors:Evers-Dörpfeld, Simone and Aeschbacher, Stefanie and Hennings, Elisa Juliane and Eken, Ceylan and Coslovsky, Michael and Rodondi, Nicolas and Springer, Anne and Ceylan, Selinda and Krempke, Melina and Meyer-Zürn, Christine and Sticherling, Christian and Bonati, Leo and Osswald, Stefan and Kühne, Michael and Conen, David
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BMJ Publishing Group
ISSN:1355-6037
e-ISSN:1468-201X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:29 Nov 2022 16:23
Deposited On:29 Nov 2022 16:23

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