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RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis

Millarte, Valentina and Spiess, Martin. (2022) RABEP1/Rabaptin5: a link between autophagy and early endosome homeostasis. Autophagy, 18. pp. 1-2.

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Official URL: https://edoc.unibas.ch/87905/

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Abstract

Selective autophagy of damaged organelles assures maintenance of cellular homeostasis in eukaryotes. While the mechanisms by which cells selectively remove dysfunctional mitochondria, lysosomes, endoplasmic reticulum and other organelles has been well characterized, little is known about specific autophagy of damaged early endosomes. In our recent study, we uncovered a new role for RABEP1/Rabaptin5, a long-established regulator of early endosome function, in targeting the autophagy machinery to early endosomes damaged by chloroquine or by internalized; Salmonella; via interaction with RB1CC1/FIP200 and ATG16L1.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spiess)
UniBasel Contributors:Spiess, Martin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
ISSN:1554-8627
e-ISSN:1554-8635
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:09 Mar 2022 11:51
Deposited On:09 Mar 2022 11:51

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