Engineering of 3D mesenchymal tissues for bone regeneration and hematopoiesis modeling

Klein, Thibaut. Engineering of 3D mesenchymal tissues for bone regeneration and hematopoiesis modeling. 2019, Doctoral Thesis, University of Basel, Faculty of Science.


Official URL: https://edoc.unibas.ch/87757/

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The bone organ has two main functions in the adult. a) It provides mechanical support and protects organs, while b) the bone marrow hosts hematopoiesis, a process ensuring lifelong production and renewal of the blood tissue. Therefore, the general aim of my thesis is to engineer mesenchymal tissues able to support bone healing and bone marrow functions. Their recapitulation in vitro by using primary hMSCs (or mesenchymal cell lines) could: (i) help fulfilling a clinical need in bone regenerative medicine by providing engineered off-the-shelf coated extracellular matrix (ECM) with tunable compositions, and (ii) provide an animal-free model to study bone biology and hematology in health and disease. These aims are addressed through a combination of hMSCs and 3D perfusion bioreactor systems.
Advisors:Martin, Ivan and Lengerke, Claudia
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Tissue Engineering (Martin)
UniBasel Contributors:Martin, Ivan and Lengerke, Claudia
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14636
Thesis status:Complete
Number of Pages:123
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss146365
edoc DOI:
Last Modified:17 Mar 2022 05:30
Deposited On:16 Mar 2022 10:35

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