Prevalence of mental disorders in acromegaly : a cross-sectional study in 81 acromegalic patients

Sievers, C. and Dimopoulou, C. and Pfister, H. and Lieb, R. and Steffin, B. and Roemmler, J. and Schopohl, J. and Mueller, M. and Schneider, H. J. and Ising, M. and Wittchen, H.-U. and Stalla, G. K.. (2009) Prevalence of mental disorders in acromegaly : a cross-sectional study in 81 acromegalic patients. Clinical endocrinology, Vol. 71. pp. 691-701.

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Official URL: http://edoc.unibas.ch/dok/A5253162

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P<Objective Emotional and behavioural alterations have been described in acromegalic patients. However, the nature and psychopathological value of these changes remained unclear. We examined whether acromegalic patients have an increased prevalence of comorbid DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, 4th Version) mental disorders in comparison to subjects with or without chronic somatic disorders. Design/patients A cross-sectional study was conducted at the Max-Planck Institute of Psychiatry and the Ludwig-Maximilians-University Munich. Eighty-one acromegalic patients were enrolled. Control subjects with (n = 3281) and without chronic somatic (n = 430) disorders were drawn from a representative sample of the German adult general population as part of the Mental Health Supplement of the German Health Interview and Examination Survey. Lifetime and 12-month prevalences of DSM-IV mental disorders were assessed with face-to-face interviews using the standardized German computer-assisted version of the Composite International Diagnostic Interview. Results Acromegalic patients had increased lifetime rates of affective disorders of 34 center dot 6% compared to 21 center dot 4% in the group with chronic somatic disorders (OR = 2 center dot 0, 95% CI 1 center dot 2-3 center dot 2) and to 11 center dot 1% in the group without chronic somatic disorders (OR = 4 center dot 4, 95% CI 2 center dot 3-8 center dot 7). Affective disorders that occurred significantly more often than in the control groups began during the putative period of already present GH excess. Higher rates of DSM-IV mental disorders were reported in those patients with additional treatment after surgery. Conclusion Acromegaly is associated with an increased prevalence and a specific pattern of affective disorders. Greater emphasis on diagnosing and treatment of mental disorders in acromegalic patients might improve the disease management.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:25
Deposited On:22 Mar 2012 13:45

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