In Vitro Production of Ergothioneine Isotopologues

Beliaeva, Mariia A. and Burn, Reto and Lim, David and Seebeck , Florian P.. (2021) In Vitro Production of Ergothioneine Isotopologues. Angewandte Chemie International Edition, 60 (10). pp. 5209-5212.

PDF - Accepted Version

Official URL: https://edoc.unibas.ch/87392/

Downloads: Statistics Overview


Ergothioneine is an emerging component of the redox homeostasis system in human cells and in microbial pathogens, such as Mycobacterium tuberculosis and Burkholderia pseudomallei. The synthesis of stable isotope-labeled ergothioneine derivatives may provide important tools for deciphering the distribution, function, and metabolism of this compound in vivo. We describe a general protocol for the production of ergothioneine isotopologues with programmable 2 H, 15 N, 13 C, 34 S, and 33 S isotope labeling patterns. This enzyme-based approach makes efficient use of commercial isotope reagents and is also directly applicable to the synthesis of radio-isotopologues.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck)
UniBasel Contributors:Seebeck, Florian Peter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
edoc DOI:
Last Modified:01 Mar 2022 02:30
Deposited On:27 Jan 2022 16:15

Repository Staff Only: item control page