Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides

Hander, Tim and Fernandez-Fernandez, Alvaro D. and Kumpf, Robert P. and Willems, Patrick and Schatowitz, Hendrik and Rombaut, Debbie and Staes, An and Nolf, Jonah and Pottie, Robin and Yao, Panfeng and Goncalves, Amanda and Pavie, Benjamin and Boller, Thomas and Gevaert, Kris and Van Breusegem, Frank and Bartels, Sebastian and Stael, Simon. (2019) Damage on plants activates Ca2+-dependent metacaspases for release of immunomodulatory peptides. Science, 363 (6433). eaar7486.

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Physical damage to cells leads to the release of immunomodulatory peptides to elicit a wound defense response in the surrounding tissue. In Arabidopsis thaliana, the plant elicitor peptide 1 (Pep1) is processed from its protein precursor, PRECURSOR OF PEP1 (PROPEP1). We demonstrate that upon damage, both at the tissue and single-cell levels, the cysteine protease METACASPASE4 (MC4) is instantly and spatiotemporally activated by binding high levels of Ca2+ and is necessary and sufficient for Pep1 maturation. Cytosol-localized PROPEP1 and MC4 react only after loss of plasma membrane integrity and prolonged extracellular Ca2+ entry. Our results reveal that a robust mechanism consisting of conserved molecular components links the intracellular and Ca2+-dependent activation of a specific cysteine protease with the maturation of damage-induced wound defense signals.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Ehemalige Einheiten Umweltwissenschaften > Pflanzenphysiologie Pathogenabwehr (Boller)
UniBasel Contributors:Boller, Thomas and Hander, Tim and Schatowitz, Hendrik and ,
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Feb 2022 14:48
Deposited On:03 Feb 2022 14:48

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