HPA axis reactivity in chronic pelvic pain : association with depression

Wingenfeld, K. and Hellhammer, D. H. and Schmidt, I. and Wagner, D. and Meinlschmidt, G. and Heim, C.. (2009) HPA axis reactivity in chronic pelvic pain : association with depression. Journal of psychosomatic obstetrics and gynaecology, Vol. 30, H. 4. pp. 282-286.

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Official URL: http://edoc.unibas.ch/dok/A5254939

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OBJECTIVES: Chronic pelvic pain (CPP) is a frequent gynecological complaint. The pathophysiology of CPP is not fully understood. The aim of this study was to determine whether the presence of depressive symptoms is associated with hypothalamic-pituitary-adrenal (HPA) axis dysfunction in CPP. METHODS: We measured neuroendocrine responses to a standardized social stress test and to a standard adrenocorticotropin (ACTH)(1-24) stimulation test in 18 patients with CPP, stratified based on the presence of high versus low self-reported depressive symptoms, compared with 24 controls. RESULTS: Women with CPP and low depression exhibited enhanced ACTH responses to psychosocial stress compared with women with CPP and high depression, whereas there were no differences in cortisol responses. In the ACTH(1-24) stimulation test, CPP patients with high depression demonstrated enhanced cortisol responses. CONCLUSION: These results suggest a relationship between self-reported depression and reactivity of the HPA axis in patients with CPP.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Klinische Psychologie und Psychiatrie
UniBasel Contributors:Meinlschmidt, Gunther
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor & Francis
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:25
Deposited On:22 Mar 2012 13:45

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