Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking

Heck, A. and Lieb, R. and Ellgas, A. and Pfister, H. and Lucae, S. and Roeske, D. and Pütz, B. and Müller-Myhsok, B. and Uhr, M. and Holsboer, F. and Ising, M.. (2009) Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, Brain and Behavior, 8 (4). pp. 464-472.

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Official URL: http://edoc.unibas.ch/dok/A5253152

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One hundred and ninety-five single nucleotide polymorphisms (SNPs) within these genes were genotyped with the Illumina BeadChip technology (HumanHap300, Human-1) in a sample of 366 mentally healthy Caucasians. Additionally, we tried to replicate our results in an independent sample of further 335 Caucasians. Personality traits in both samples were assessed with the German version of Cloninger's Tridimensional Personality Questionnaire. From 30 SNPs showing associations at a nominal level of significance, two intronic SNPs, rs2770296 and rs927544, both located in the HTR2A gene, withstood correction for multiple testing. These SNPs were associated with the personality trait novelty seeking. The effect of rs927544 could be replicated for the novelty seeking subscale extravagance, and the same SNP was also associated with extravagance inthe combined samples. Our results show that HTR2A polymorphisms modulate facets of novelty seeking behaviour in healthy adults suggesting that serotonergic neurotransmission is involved in this phenotype.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Health & Intervention > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind and Heck, Angela
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:29 Nov 2017 07:40
Deposited On:22 Mar 2012 13:45

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