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Artificial Melanogenesis by Confining Melanin/Polydopamine Production inside Polymersomes

Meyer, Claire E. and Schoenenberger, Cora-Ann and Wehr, Riccardo P. and Wu, Dalin and Palivan, Cornelia G.. (2021) Artificial Melanogenesis by Confining Melanin/Polydopamine Production inside Polymersomes. Macromolecular Bioscience, 21 (12). p. 2100249.

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Abstract

Melanin and polydopamine are potent biopolymers for the development of biomedical nanosystems. However, applications of melanin or polydopamine-based nanoparticles are limited by drawbacks related to a compromised colloidal stability over long time periods and associated cytotoxicity. To overcome these hurdles, a novel strategy is proposed that mimics the confinement of natural melanin in melanosomes. Melanosome mimics are developed by co-encapsulating the melanin/polydopamine precursors L-DOPA/dopamine with melanogenic enzyme Tyrosinase within polymersomes. The conditions of polymersome formation are optimized to obtain melanin/polydopamine polymerization within the cavity of the polymersomes. Similar to native melanosomes, polymersomes containing melanin/polydopamine show long-term colloidal stability, cell-compatibility, and potential for cell photoprotection. This novel kind of artificial melanogenesis is expected to inspire new applications of the confined melanin/polydopamine biopolymers.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Makromolekulare Chemie (Meier)
05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Palivan, Cornelia G and Meyer, Claire and Schönenberger, Cora-Ann and Wehr, Riccardo Pascal and Wu, Dalin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:1616-5187
e-ISSN:1616-5195
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:17 May 2022 14:01
Deposited On:19 Jan 2022 09:21

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