Recurrent Circuitry for Balancing Sleep Need and Sleep

Donlea, Jeffrey M. and Pimentel, Diogo and Talbot, Clifford B. and Kempf, Anissa and Omoto, Jaison J. and Hartenstein, Volker and Miesenböck, Gero. (2018) Recurrent Circuitry for Balancing Sleep Need and Sleep. Neuron, 97 (2). pp. 378-389.e4.

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Official URL: https://edoc.unibas.ch/85415/

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Sleep-promoting neurons in the dorsal fan-shaped body (dFB) of Drosophila are integral to sleep homeostasis, but how these cells impose sleep on the organism is unknown. We report that dFB neurons communicate via inhibitory transmitters, including allatostatin-A (AstA), with interneurons connecting the superior arch with the ellipsoid body of the central complex. These "helicon cells" express the galanin receptor homolog AstA-R1, respond to visual input, gate locomotion, and are inhibited by AstA, suggesting that dFB neurons promote rest by suppressing visually guided movement. Sleep changes caused by enhanced or diminished allatostatinergic transmission from dFB neurons and by inhibition or optogenetic stimulation of helicon cells support this notion. Helicon cells provide excitation to R2 neurons of the ellipsoid body, whose activity-dependent plasticity signals rising sleep pressure to the dFB. By virtue of this autoregulatory loop, dFB-mediated inhibition interrupts processes that incur a sleep debt, allowing restorative sleep to rebalance the books. VIDEO ABSTRACT.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Neurobiology (Kempf)
UniBasel Contributors:Kempf, Anissa
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Feb 2022 10:57
Deposited On:28 Feb 2022 10:57

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