Site-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones

Kudashev, Anton and Baudoin, Olivier. (2021) Site-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones. Chemistry - A European Journal, 27 (70). pp. 17688-17694.

[img] PDF - Published Version
Available under License CC BY-NC (Attribution-NonCommercial).


Official URL: https://edoc.unibas.ch/85350/

Downloads: Statistics Overview


A ligand-controlled site-selective C(sp; 3; )-H arylation of heteroaromatic ketones has been developed using Pd catalysis. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- to β-arylation was realized by addition of a pyridone ligand. The α-arylation process showed broad scope and high site- and chemoselectivity, whereas the β-arylation was more limited. Mechanistic investigations suggested that α-arylation occurs through C-H activation/oxidative addition/reductive elimination whereas β-arylation involves desaturation and aryl insertion.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Synthetische Chemie (Baudoin)
UniBasel Contributors:Baudoin, Olivier
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
edoc DOI:
Last Modified:24 Jan 2022 14:13
Deposited On:24 Jan 2022 14:13

Repository Staff Only: item control page