GA4GH: International policies and standards for data sharing across genomic research and healthcare

Rehm, Heidi L. and Page, Angela J. H. and Smith, Lindsay and Adams, Jeremy B. and Alterovitz, Gil and Babb, Lawrence J. and Barkley, Maxmillian P. and Baudis, Michael and Beauvais, Michael J. S. and Beck, Tim and Beckmann, Jacques S. and Beltran, Sergi and Bernick, David and Bernier, Alexander and Bonfield, James K. and Boughtwood, Tiffany F. and Bourque, Guillaume and Bowers, Sarion R. and Brookes, Anthony J. and Brudno, Michael and Brush, Matthew H. and Bujold, David and Burdett, Tony and Buske, Orion J. and Cabili, Moran N. and Cameron, Daniel L. and Carroll, Robert J. and Casas-Silva, Esmeralda and Chakravarty, Debyani and Chaudhari, Bimal P. and Chen, Shu Hui and Cherry, J. Michael and Chung, Justina and Cline, Melissa and Clissold, Hayley L. and Cook-Deegan, Robert M. and Courtot, Mélanie and Cunningham, Fiona and Cupak, Miro and Davies, Robert M. and Denisko, Danielle and Doerr, Megan J. and Dolman, Lena I. and Dove, Edward S. and Dursi, L. Jonathan and Dyke, Stephanie O. M. and Eddy, James A. and Eilbeck, Karen and Ellrott, Kyle P. and Fairley, Susan and Fakhro, Khalid A. and Firth, Helen V. and Fitzsimons, Michael S. and Fiume, Marc and Flicek, Paul and Fore, Ian M. and Freeberg, Mallory A. and Freimuth, Robert R. and Fromont, Lauren A. and Fuerth, Jonathan and Gaff, Clara L. and Gan, Weiniu and Ghanaim, Elena M. and Glazer, David and Green, Robert C. and Griffith, Malachi and Griffith, Obi L. and Grossman, Robert L. and Groza, Tudor and Guidry Auvil, Jaime M. and Guigó, Roderic and Gupta, Dipayan and Haendel, Melissa A. and Hamosh, Ada and Hansen, David P. and Hart, Reece K. and Hartley, Dean Mitchell and Haussler, David and Hendricks-Sturrup, Rachele M. and Ho, Calvin W. L. and Hobb, Ashley E. and Hoffman, Michael M. and Hofmann, Oliver M. and Holub, Petr and Hsu, Jacob Shujui and Hubaux, Jean-Pierre and Hunt, Sarah E. and Husami, Ammar and Jacobsen, Julius O. and Jamuar, Saumya S. and Janes, Elizabeth L. and Jeanson, Francis and Jené, Aina and Johns, Amber L. and Joly, Yann and Jones, Steven J. M. and Kanitz, Alexander and Kato, Kazuto and Keane, Thomas M. and Kekesi-Lafrance, Kristina and Kelleher, Jerome and Kerry, Giselle and Khor, Seik-Soon and Knoppers, Bartha M. and Konopko, Melissa A. and Kosaki, Kenjiro and Kuba, Martin and Lawson, Jonathan and Leinonen, Rasko and Li, Stephanie and Lin, Michael F. and Linden, Mikael and Liu, Xianglin and Liyanage, Isuru Udara and Lopez, Javier and Lucassen, Anneke M. and Lukowski, Michael and Mann, Alice L. and Marshall, John and Mattioni, Michele and Metke-Jimenez, Alejandro and Middleton, Anna and Milne, Richard J. and Molnár-Gábor, Fruzsina and Mulder, Nicola and Munoz-Torres, Monica C. and Nag, Rishi and Nakagawa, Hidewaki and Nasir, Jamal and Navarro, Arcadi and Nelson, Tristan H. and Niewielska, Ania and Nisselle, Amy and Niu, Jeffrey and Nyrönen, Tommi H. and O'Connor, Brian D. and Oesterle, Sabine and Ogishima, Soichi and Wang, Vivian Ota and Paglione, Laura A. D. and Palumbo, Emilio and Parkinson, Helen E. and Philippakis, Anthony A. and Pizarro, Angel D. and Prlic, Andreas and Rambla, Jordi and Rendon, Augusto and Rider, Renee A. and Robinson, Peter N. and Rodarmer, Kurt W. and Rodriguez, Laura Lyman and Rubin, Alan F. and Rueda, Manuel and Rushton, Gregory A. and Ryan, Rosalyn S. and Saunders, Gary I. and Schuilenburg, Helen and Schwede, Torsten and Scollen, Serena and Senf, Alexander and Sheffield, Nathan C. and Skantharajah, Neerjah and Smith, Albert V. and Sofia, Heidi J. and Spalding, Dylan and Spurdle, Amanda B. and Stark, Zornitza and Stein, Lincoln D. and Suematsu, Makoto and Tan, Patrick and Tedds, Jonathan A. and Thomson, Alastair A. and Thorogood, Adrian and Tickle, Timothy L. and Tokunaga, Katsushi and Törnroos, Juha and Torrents, David and Upchurch, Sean and Valencia, Alfonso and Guimera, Roman Valls and Vamathevan, Jessica and Varma, Susheel and Vears, Danya F. and Viner, Coby and Voisin, Craig and Wagner, Alex H. and Wallace, Susan E. and Walsh, Brian P. and Williams, Marc S. and Winkler, Eva C. and Wold, Barbara J. and Wood, Grant M. and Woolley, J. Patrick and Yamasaki, Chisato and Yates, Andrew D. and Yung, Christina K. and Zass, Lyndon J. and Zaytseva, Ksenia and Zhang, Junjun and Goodhand, Peter and North, Kathryn and Birney, Ewan. (2021) GA4GH: International policies and standards for data sharing across genomic research and healthcare. Cell Genomics, 1 (2). p. 100029.

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Official URL: https://edoc.unibas.ch/85165/

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The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Zavolan)
UniBasel Contributors:Schwede, Torsten and Kanitz, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Nov 2021 14:50
Deposited On:22 Nov 2021 14:50

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