Cryptic transmission of SARS-CoV-2 in Washington state

Bedford, Trevor and Greninger, Alexander L. and Roychoudhury, Pavitra and Starita, Lea M. and Famulare, Michael and Huang, Meei-Li and Nalla, Arun and Pepper, Gregory and Reinhardt, Adam and Xie, Hong and Shrestha, Lasata and Nguyen, Truong N. and Adler, Amanda and Brandstetter, Elisabeth and Cho, Shari and Giroux, Danielle and Han, Peter D. and Fay, Kairsten and Frazar, Chris D. and Ilcisin, Misja and Lacombe, Kirsten and Lee, Jover and Kiavand, Anahita and Richardson, Matthew and Sibley, Thomas R. and Truong, Melissa and Wolf, Caitlin R. and Nickerson, Deborah A. and Rieder, Mark J. and Englund, Janet A. and Seattle Flu Study Investigators, and Hadfield, James and Hodcroft, Emma B. and Huddleston, John and Moncla, Louise H. and Müller, Nicola F. and Neher, Richard A. and Deng, Xianding and Gu, Wei and Federman, Scot and Chiu, Charles and Duchin, Jeffrey S. and Gautom, Romesh and Melly, Geoff and Hiatt, Brian and Dykema, Philip and Lindquist, Scott and Queen, Krista and Tao, Ying and Uehara, Anna and Tong, Suxiang and MacCannell, Duncan and Armstrong, Gregory L. and Baird, Geoffrey S. and Chu, Helen Y. and Shendure, Jay and Jerome, Keith R.. (2020) Cryptic transmission of SARS-CoV-2 in Washington state. Science, 370 (6516). pp. 571-575.

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Official URL: https://edoc.unibas.ch/84944/

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Abstract

After its emergence in Wuhan, China, in late November or early December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. Genome sequencing of SARS-CoV-2 allows the reconstruction of its transmission history, although this is contingent on sampling. We analyzed 453 SARS-CoV-2 genomes collected between 20 February and 15 March 2020 from infected patients in Washington state in the United States. We find that most SARS-CoV-2 infections sampled during this time derive from a single introduction in late January or early February 2020, which subsequently spread locally before active community surveillance was implemented.

Faculties and Departments:	05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:	Neher, Richard A
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
e-ISSN:	1095-9203
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Green Open Access
Identification Number:	doi: 10.1126/science.abc0523 pmid: 32913002
Last Modified:	24 Feb 2022 11:49
Deposited On:	24 Feb 2022 11:49

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