Asynchrony between virus diversity and antibody selection limits influenza virus evolution

Morris, Dylan H. and Petrova, Velislava N. and Rossine, Fernando W. and Parker, Edyth and Grenfell, Bryan T. and Neher, Richard A. and Levin, Simon A. and Russell, Colin A.. (2020) Asynchrony between virus diversity and antibody selection limits influenza virus evolution. eLife, 9. e62105.

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Official URL: https://edoc.unibas.ch/84919/

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Seasonal influenza viruses create a persistent global disease burden by evolving to escape immunity induced by prior infections and vaccinations. New antigenic variants have a substantial selective advantage at the population level, but these variants are rarely selected within-host, even in previously immune individuals. Using a mathematical model, we show that the temporal asynchrony between within-host virus exponential growth and antibody-mediated selection could limit within-host antigenic evolution. If selection for new antigenic variants acts principally at the point of initial virus inoculation, where small virus populations encounter well-matched mucosal antibodies in previously-infected individuals, there can exist protection against reinfection that does not regularly produce observable new antigenic variants within individual infected hosts. Our results provide a theoretical explanation for how virus antigenic evolution can be highly selective at the global level but nearly neutral within-host. They also suggest new avenues for improving influenza control.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Computational Modeling of Biological Processes (Neher)
UniBasel Contributors:Neher, Richard A
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:eLife Sciences Publications
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Nov 2021 13:07
Deposited On:24 Nov 2021 13:07

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