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The influence of actin and a phosphorylation site in Mec1 on DNA repair

Hurst, Verena/V.. The influence of actin and a phosphorylation site in Mec1 on DNA repair. 2021, Doctoral Thesis, University of Basel, Associated Institution, Faculty of Science.

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Abstract

This thesis investigates the role of actin in DNA repair as well as transcription replication collision and how both processes are controlled.Of interest to the reader may be the manuscript draft entitled "Altered F-/G-actin balance disrupts the repair of oxidative DNA damage", which is available in this Thesis only and has not been published otherwise. Readers interested in a specific publication, should access the publication online:
(1) Hurst, V. et al. (2021): Cytoskeleton integrity influences XRCC1 and PCNA dynamics at DNA damage. Mol Biol Cell: mbcE20100680,
(2) Hurst, V. et al. (2021). A regulatory phosphorylation site on Mec1 controls RNAP II and III occupancy on chromatin during replication stress. EMBO J: e108439,
(3) Hurst, V. and S.M. Gasser (2019). The study of protein recruitment to laser-induced DNA lesions can be distorted by photoconversion of the DNA binding dye Hoechst. F1000Res 8: 104, or
(4) Hurst, V. et al. (2019). Nuclear Actin and Actin-Binding Proteins in DNA Repair. Trends Cell Biol 29(6): 462-476.
Advisors:Gasser, Susan and Schär, Primo Leo
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe > Urologie Kliniken BL (Gasser)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe > Urologie Kliniken BL (Gasser)
UniBasel Contributors:Gasser, Susan and Schär, Primo Leo
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14417
Thesis status:Complete
Number of Pages:183
Language:English
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss144179
edoc DOI:
Last Modified:03 Nov 2021 05:30
Deposited On:02 Nov 2021 16:31

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