A nomogram to predict unfavourable outcome in patients receiving oral anticoagulants for atrial fibrillation after stroke

Cappellari, Manuel and Seiffge, David J. and Koga, Masatoshi and Paciaroni, Maurizio and Forlivesi, Stefano and Turcato, Gianni and Bovi, Paolo and Yoshimura, Sohei and Tanaka, Kanta and Shiozawa, Masayuki and Yoshimoto, Takeshi and Miwa, Kaori and Takagi, Masahito and Inoue, Manabu and Yamagami, Hiroshi and Caso, Valeria and Tsivgoulis, Georgios and Venti, Michele and Acciarresi, Monica and Alberti, Andrea and Toni, Danilo and Polymeris, Alexandros and Bonetti, Bruno and Agnelli, Giancarlo and Toyoda, Kazunori and Engelter, Stefan T. and De Marchis, Gian Marco and Samurai-Nvaf, RAF-Noac and Noacisp Long-Term, and Verona Study Groups, . (2020) A nomogram to predict unfavourable outcome in patients receiving oral anticoagulants for atrial fibrillation after stroke. European stroke journal, 5 (4). pp. 384-393.

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Official URL: https://edoc.unibas.ch/84728/

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It is unknown whether the type of treatment (direct oral anticoagulant versus vitamin K antagonist) and the time of treatment introduction (early versus late) may affect the functional outcome in stroke patients with atrial fibrillation. We aimed to develop and validate a nomogram model including direct oral anticoagulant/vitamin K antagonist and early/late oral anticoagulant introduction for predicting the probability of unfavourable outcome after stroke in atrial fibrillation-patients.; We conducted an individual patient data analysis of four prospective studies. Unfavourable functional outcome was defined as three-month modified Rankin Scale score 3 -6. To generate the nomogram, five independent predictors including age ( 25), acute revascularisation treatments (yes, reference, or no), direct oral anticoagulant (reference) or vitamin K antagonist, and early (7 days, reference) or late (8--30) anticoagulant introduction entered into a final logistic regression model. The discriminative performance of the model was assessed by using the area under the receiver operating characteristic curve.; A total of 2102 patients with complete data for generating the nomogram was randomly dichotomised into training (; n; = 1553) and test (; n; = 549) sets. The area under the receiver operating characteristic curve was 0.822 (95% confidence interval, CI: 0.800--0.844) in the training set and 0.803 (95% CI: 0.764--0.842) in the test set. The model was adequately calibrated (9.852;; p; = 0.276 for the Hosmer--Lemeshow test).; Our nomogram is the first model including type of oral anticoagulant and time of treatment introduction to predict the probability of three-month unfavourable outcome in a large multicentre cohort of stroke patients with atrial fibrillation.
Faculties and Departments:03 Faculty of Medicine
UniBasel Contributors:Polymeris, Alexandros
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 Nov 2021 13:02
Deposited On:24 Nov 2021 13:02

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