Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals

Maushart, Claudia Irene and Senn, Jaël Rut and Loeliger, Rahel Catherina and Kraenzlin, Marius E. and Müller, Julian and Becker, Anton S. and Balaz, Miroslav and Wolfrum, Christian and Burger, Irene A. and Betz, Matthias Johannes. (2021) Free Thyroxine Levels are Associated with Cold Induced Thermogenesis in Healthy Euthyroid Individuals. Frontiers in Endocrinology, 12. p. 666595.

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Thyroid hormone (TH) is an important regulator of mammalian metabolism and facilitates cold induced thermogenesis (CIT) in brown adipose tissue (BAT). Profound hypothyroidism or hyperthyroidism lead to alterations in BAT function and CIT. In euthyroid humans the inter-individual variation of thyroid hormones is relatively large. Therefore, we investigated whether levels of free thyroxine (T4) or free triiodothyronine (T3) are positively associated with CIT in euthyroid individuals. We performed an observational study in 79 healthy, euthyroid volunteers (mean age 25.6 years, mean BMI 23.0 kg · m; -2; ). Resting energy expenditure (REE) was measured by indirect calorimetry during warm conditions (EE; warm; ) and after a mild cold stimulus of two hours (EE; cold; ). CIT was calculated as the difference between EE; cold; and EE; warm; . BAT activity was assessed by; 18; F-FDG-PET after a mild cold stimulus in a subset of 26 participants. EE; cold; and CIT were significantly related to levels of free T4 (R; 2; = 0.11, p=0.0025 and R; 2; = 0.13, p=0.0011, respectively) but not to free T3 and TSH. Cold induced BAT activity was also associated with levels of free T4 (R; 2; = 0.21, p=0.018). CIT was approximately fourfold higher in participants in the highest tertile of free T4 as compared to the lowest tertile. Additionally, free T4 was weakly, albeit significantly associated with outdoor temperature seven days prior to the respective study visit (R; 2; = 0.06, p=0.037). These finding suggests that variations in thyroid hormone levels within the euthyroid range are related to the capability to adapt to cool temperatures and affect energy balance.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Endokrinologie / Diabetologie
UniBasel Contributors:Betz, Matthias Johannes Maximilian
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 Nov 2022 16:49
Deposited On:18 Nov 2022 16:49

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