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Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions

van Vliet, Simon and Dal Co, Alma and Winkler, Annina R. and Spriewald, Stefanie and Stecher, Bärbel and Ackermann, Martin. (2018) Spatially Correlated Gene Expression in Bacterial Groups: The Role of Lineage History, Spatial Gradients, and Cell-Cell Interactions. Cell Systems, 6 (4). pp. 496-507.e6.

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Official URL: https://edoc.unibas.ch/84531/

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Abstract

Gene expression levels in clonal bacterial groups have been found to be spatially correlated. These correlations can partly be explained by the shared lineage history of nearby cells, although they could also arise from local cell-cell interactions. Here, we present a quantitative framework that allows us to disentangle the contributions of lineage history, long-range spatial gradients, and local cell-cell interactions to spatial correlations in gene expression. We study pathways involved in toxin production, SOS stress response, and metabolism in Escherichia coli microcolonies and find for all pathways that shared lineage history is the main cause of spatial correlations in gene expression levels. However, long-range spatial gradients and local cell-cell interactions also contributed to spatial correlations in SOS response, amino acid biosynthesis, and overall metabolic activity. Together, our data show that the phenotype of a cell is influenced by its lineage history and population context, raising the question of whether bacteria can arrange their activities in space to perform functions they cannot achieve alone.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
UniBasel Contributors:van Vliet, Simon
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:2405-4712
e-ISSN:2405-4720
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Oct 2021 14:47
Deposited On:06 Oct 2021 14:47

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