Bioorthogonal strategies for the in vivo synthesis or release of drugs

Lozhkin, Boris and Ward, Thomas R.. (2021) Bioorthogonal strategies for the in vivo synthesis or release of drugs. Bioorganic & medicinal chemistry, 45. p. 116310.

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Official URL: https://edoc.unibas.ch/84515/

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The site-specific delivery of antitumor agents is a rapidly developing field that relies on prodrug activation and uncaging strategies. For this purpose, a wide range of homogeneous and heterogeneous biocompatible activators/catalysts have been developed to convert caged drugs with low toxicity and high stability in physiological settings into active substances in a bioorthogonal manner. The current methods allow for the site-specific delivery of activators and prodrugs to organelles, target cells, or tumors in living organisms. Here, we present an overview of the latest advances in catalytic drugs, highlighting the expanding toolbox of bioorthogonal activation strategies made possible by transition metals acting as activators or catalysts.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Bioanorganische Chemie (Ward)
UniBasel Contributors:Ward, Thomas R. R.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Sep 2021 09:12
Deposited On:22 Sep 2021 09:12

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