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Comorbid Mental Disorders during Long-Term Course in a Nationwide Cohort of Patients with Anorexia Nervosa

Steinhausen, Hans-Christoph and Villumsen, Martin Dalgaard and Hørder, Kirsten and Winkler, Laura Al-Dakhiel and Bilenberg, Niels and Støving, René Klinkby. (2021) Comorbid Mental Disorders during Long-Term Course in a Nationwide Cohort of Patients with Anorexia Nervosa. International Journal of Eating Disorders, 54 (9). pp. 1608-1618.

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Official URL: https://edoc.unibas.ch/84462/

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Abstract

Comorbid mental disorders in anorexia nervosa during long-term course require detailed studies.; This matched cohort study was based on nationwide Danish register data of all patients born 1961-2008 with a first-time ICD-10 diagnosis of anorexia nervosa (AN) between 1994 and 2018 at age 8-32 and matched controls taken from all individuals without an eating disorder (ED). For nine categories of non-eating mental disorders, time from date of first AN-diagnosis (inclusion date) to time of first diagnosis, accounting for censoring, was studied by use of time-stratified Cox models.; A total of 9,985 patients with AN (93.5% females) and 49,351 matched controls were followed for a median (IQR) of 9.0 (4.4-15.7) years. For patients, there was about 25% and 55% risk of receiving any non-ED disorder during the first 2 years and two decades after inclusion, respectively. A hazard ratio (HR) of seven for any non-ED was found for the first 12 months after inclusion, a ratio that reduced to two at five or more years after inclusion. During the first years, large HRs ranging in 6-9 were found for affective, autism spectrum, personality, and obsessive-compulsive disorders with the latter displaying the highest continuous increased risk. The HR at 12 months after inclusion was highest for any non-ED disorder and affective disorders in patients aged 8-13 at diagnosis.; Comorbid mental disorders in AN are most frequently diagnosed in the first years after diagnosis of AN and on longer terms imply a double immediate risk.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0276-3478
e-ISSN:1098-108X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:11 Oct 2021 07:07
Deposited On:11 Oct 2021 07:07

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