Biodegradable Harmonophores for Targeted High-Resolution; In Vivo; Tumor Imaging

Sonay, Ali Yasin and Kalyviotis, Konstantinos and Yaganoglu, Sine and Unsal, Aysen and Konantz, Martina and Teulon, Claire and Lieberwirth, Ingo and Sieber, Sandro and Jiang, Shuai and Behzadi, Shahed and Crespy, Daniel and Landfester, Katharina and Roke, Sylvie and Lengerke, Claudia and Pantazis, Periklis. (2021) Biodegradable Harmonophores for Targeted High-Resolution; In Vivo; Tumor Imaging. ACS Nano, 15 (3). pp. 4144-4154.

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Official URL: https://edoc.unibas.ch/83869/

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Optical imaging probes have played a major role in detecting and monitoring a variety of diseases. In particular, nonlinear optical imaging probes, such as second harmonic generating (SHG) nanoprobes, hold great promise as clinical contrast agents, as they can be imaged with little background signal and unmatched long-term photostability. As their chemical composition often includes transition metals, the use of inorganic SHG nanoprobes can raise long-term health concerns. Ideally, contrast agents for biomedical applications should be degraded; in vivo; without any long-term toxicological consequences to the organism. Here, we developed biodegradable harmonophores (bioharmonophores) that consist of polymer-encapsulated, self-assembling peptides that generate a strong SHG signal. When functionalized with tumor cell surface markers, these reporters can target single cancer cells with high detection sensitivity in zebrafish embryos; in vivo; . Thus, bioharmonophores will enable an innovative approach to cancer treatment using targeted high-resolution optical imaging for diagnostics and therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Stem Cells and Hematopoiesis (Lengerke)
UniBasel Contributors:Konantz, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Chemical Society
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2021 09:36
Deposited On:31 Aug 2021 09:36

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