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Intima-Media-Dicke der Arteria carotis communis einer gesunden und einer herzkranken Schweizer Population

Müller, Michèle Anne. Intima-Media-Dicke der Arteria carotis communis einer gesunden und einer herzkranken Schweizer Population. 2021, Master Thesis, University of Basel, Faculty of Medicine.

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Official URL: https://edoc.unibas.ch/83773/

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Abstract

Backround
Cardiovascular diseases continue to be among the most frequent causes of death in western industrialized countries. According to calculations, in the USA more than 130 million adults with cardiovascular disease are expected to have cardiovascular disease in 2035. Intima-Media-thickness (IMT) is a widely used marker for atherosclerosis and can also be used to predict cardiovascular events or prepare a risk assessment for cardiovascular disease. Due to the non-invasive character of IMT measurement, the easy availability, as well as the user-friendliness, IMT measurement via B-mode ultrasound is a popular tool in clinical practice. For the healthy Swiss population there are no reference values of the cIMT yet. The application of this measurement, the resulting collection and comparison of data from healthy patients and patients with heart disease, will improve the prevention of cardiovascular disease in the Swiss population. Considering the steadily increasing incidence of cardiovascular diseases, the relevance is given.
Method
Intima-media thickness was measured by imaging B-mode ultrasound of the common carotid artery. Two collectives were examined. The first collective consisted of 279 healthy non-smokers between 50 and 99 years of age. As a counterpart, 87 persons with already diagnosed heart failure between the ages of 21 and 89 years were examined. In addition, anthropometric measures (body composition, waist-hip ratio), parameters of physical fitness (hand, leg, bounce, balance, cardiorespiratory performance) and other measures of cardiovascular diagnostics (flow-mediated vasodilation, pulse wave velocity) were collected. The measurement of the cIMT was performed by experienced test directors of the DSBG (Department of Sports, Exercise and Health) Basel prior to the echocardiography examination.
Results
For healthy volunteers, the average cIMT (measured sonic heads) of men does not differ significantly from the average cIMT of women (0.78 (IQR 0.67 - 0.87 vs. 0.73 (IQR 0.66 - 0.85) mm, p= 0.113). In patients with cardiac disease, there are no significant gender differences in cIMT (p > 0.05). No significant difference in cIMT between healthy and sick subjects was also found (p > 0.05). It was shown that cIMT of the farwall increases significantly with age (p<0.001).
Conclusion
Between two age-adjusted cohorts (healthy vs. cardiac) there was no significant difference in IMT between the two subgroups. However, a significant increase in IMT was found in both groups with age. In contrast, no significant influence of fitness on IMT could be shown after addition of further cardiovascular risk factors.
Advisors:Königstein, Karsten and Schmidt-Trucksäss, Arno
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
UniBasel Contributors:Königstein, Karsten and Schmidt-Trucksäss, Arno
Item Type:Thesis
Thesis Subtype:Master Thesis
Thesis no:1
Thesis status:Complete
Last Modified:29 Jun 2021 04:30
Deposited On:28 Jun 2021 08:16

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