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Extracellular matrix structure governs invasion resistance in bacterial biofilms

Nadell, Carey D. and Drescher, Knut and Wingreen, Ned S. and Bassler, Bonnie L.. (2015) Extracellular matrix structure governs invasion resistance in bacterial biofilms. ISME Journal, 9 (8). pp. 1700-1709.

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Abstract

Many bacteria are highly adapted for life in communities, or biofilms. A defining feature of biofilms is the production of extracellular matrix that binds cells together. The biofilm matrix provides numerous fitness benefits, including protection from environmental stresses and enhanced nutrient availability. Here we investigate defense against biofilm invasion using the model bacterium Vibrio cholerae. We demonstrate that immotile cells, including those identical to the biofilm resident strain, are completely excluded from entry into resident biofilms. Motile cells can colonize and grow on the biofilm exterior, but are readily removed by shear forces. Protection from invasion into the biofilm interior is mediated by the secreted protein RbmA, which binds mother-daughter cell pairs to each other and to polysaccharide components of the matrix. RbmA, and the invasion protection it confers, strongly localize to the cell lineages that produce it.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
UniBasel Contributors:Drescher, Knut
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
ISSN:1751-7362
e-ISSN:1751-7370
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:23 Jun 2021 09:01
Deposited On:23 Jun 2021 09:01

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