Filaments in curved streamlines: Rapid formation of; Staphylococcus aureus; biofilm streamers

Kim, Minyoung Kevin and Drescher, Knut and Pak, On Shun and Bassler, Bonnie L. and Stone, Howard A.. (2014) Filaments in curved streamlines: Rapid formation of; Staphylococcus aureus; biofilm streamers. New Journal of Physics, 16 (6). 065024.

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Official URL: https://edoc.unibas.ch/83561/

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Biofilms are surface-associated conglomerates of bacteria that are highly resistant to antibiotics. These bacterial communities can cause chronic infections in humans by colonizing, for example, medical implants, heart valves, or lungs.; Staphylococcus aureus; , a notorious human pathogen, causes some of the most common biofilm-related infections. Despite the clinical importance of; S. aureus; biofilms, it remains mostly unknown how physical effects, in particular flow, and surface structure influence biofilm dynamics. Here we use model microfluidic systems to investigate how environmental factors, such as surface geometry, surface chemistry, and fluid flow affect biofilm development in; S. aureus.; We discovered that; S. aureus; rapidly forms flow-induced, filamentous biofilm streamers, and furthermore if surfaces are coated with human blood plasma, streamers appear within minutes and clog the channels more rapidly than if the channels are uncoated. To understand how biofilm streamer filaments reorient in flows with curved streamlines to bridge the distances between corners, we developed a mathematical model based on resistive force theory of slender filaments. Understanding physical aspects of biofilm formation in; S. aureus; may lead to new approaches for interrupting biofilm formation of this pathogen.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
UniBasel Contributors:Drescher, Knut
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:IOP Publishing
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:23 Jun 2021 08:50
Deposited On:23 Jun 2021 08:50

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