Respiratory pathophysiology of panic disorder : an ambulatory monitoring study

Pfaltz, M. C. and Michael, T. and Grossman, P. and Blechert, J. and Wilhelm, F. H.. (2009) Respiratory pathophysiology of panic disorder : an ambulatory monitoring study. Psychosomatic medicine, 71 (8). pp. 869-876.

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Official URL: http://edoc.unibas.ch/dok/A5250311

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Objective: To assess the external validity of laboratory baselines in panic disorder (PD), frequently associated with respiratory pattern abnormalities like increased respiratory variability and sighing, implying a stable pathophysiologic trait characteristic. Methods: Physical activity and a variety of breath-by-breath volumetric, timing, and variability measures of respiration were recorded in the daily life of 26 patients with PD and 26 healthy controls (HC), using a novel ambulatory monitoring system optimized for reliable assessment of respiratory pattern. Data were stratified for physical activity to eliminate its confounding effects. Results: Groups showed strong and consistent diurnal patterns in almost all respiratory variables. However, patients with PD did not differ from HC regarding any of the respiratory timing, volumetric and variability measures, with negligible group effect sizes for all measures. Patients with fewer self-reported respiratory symptoms of anxiety exhibited more pronounced rapid shallow breathing as well as diminished total breath time and its variability. Conclusions: Despite state-of-the-art ambulatory assessment and sufficient statistical power to detect respiratory alterations previously observed in the laboratory, we found no evidence for such alterations in PD patients' daily life. Neither the total PD group nor patients with particularly pronounced respiratory symptomatology displayed increased respiratory variability. These results caution against interpreting results from laboratory baselines in PD as reflecting a stable trait characteristic. Rather, they likely represent a state-trait interaction due to enhanced reactivity of PD patients to novel environments. These results challenge aspects of respiratory theories of PD that were based on laboratory findings.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Psychosomatik
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Psychosomatik
07 Faculty of Psychology
UniBasel Contributors:Grossmann, Paul and Grossmann, Paul and Michael, Tanja and Pfaltz, Monique Christine and Wilhelm, Frank H
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Lippincott Williams & Wilkins
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:28 Sep 2017 15:23
Deposited On:22 Mar 2012 13:43

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