Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: A scoping review

Appenzeller-Herzog, Christian and Hartleif, Steffen and Vionnet, Julien. (2021) Clinical parameters and biomarkers predicting spontaneous operational tolerance after liver transplantation: A scoping review. American Journal of Transplantation, 21 (10). pp. 3312-3323.

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Official URL: https://edoc.unibas.ch/82812/

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Indefinite allograft acceptance after immunosuppression withdrawal (ISW), also known as operational tolerance (OT), can occur spontaneously after liver transplantation (LT) but reliable and reproducible prognosis of OT versus non-OT outcomes remains elusive. To prime this, systematic extraction of OT-predictive factors from the literature is crucial. We provide the first comprehensive identification and synthesis of clinical parameters and biomarkers predicting spontaneous OT in non-autoimmune/non-replicative viral LT recipients selected for ISW. We searched Embase, Medline, the Cochrane Central Register of Controlled Trials, clinicaltrials.gov, and the World Health Organization International Clinical Trials Registry Platform for articles, conference abstracts, and ongoing trials. We contacted principal investigators of stand-alone abstracts and ongoing trials for unpublished data and screened citations and references of eligible articles. 23 articles reporting on 11 completed ISW studies, 13 abstracts, and five trial registry entries were included. Longer time between LT and ISW was the only clinical parameter that may increase the incidence of OT. Prognostic biomarkers conspicuously differed between pediatric and adult ISW candidates. These included allograft gene expression patterns and peripheral blood immune exhaustion markers for adults, and histological allograft scores for children. Our results will foster cross-validation efforts to facilitate safe and harmonized candidate selection for successful ISW.
Faculties and Departments:10 Zentrale universitäre Einrichtungen > Universitätsbibliothek
UniBasel Contributors:Appenzeller-Herzog, Christian
Item Type:Article, refereed
Article Subtype:Research Article
ISSN: 1600-6135
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:13 Oct 2021 08:36
Deposited On:13 Oct 2021 06:48

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