Development, Implementation and Testing of an Integrated Model of Care for Allogeneic SteM Cell TransplantatIon faciLitated by eHealth Technology – The SMILe Study

This dissertation addresses the development of an integrated model of care for allogeneic SteM cell transplantatIon faciLitated by eHealth – SMILe - as well as the implementation and testing in a first clinical setting. SMILe was developed following a stepwise approach combining implementation-, behavioral-, and computer science methods. Guided by implementation science methods, a thorough contextual analysis identifying the target organization’s structural characteristics, practice patterns in view of chronic illness management and technology openness, was performed. Based on the results and current evidence by applying behavioral theory as well as a user-centered design embedded within an agile software development process, the SMILe care models content and mode of delivery has been developed. SMILe is currently tested within a hybrid 1 implementation effectiveness randomized controlled trial at a first clinical setting. Therefore, this dissertation’s contributes both clinical and methodological. That is, the SMILe is expected to improve alloSCT patients’ biopsychosocial outcomes while providing guidance on the used methodologies and serving as blueprints for other projects to develop, scale up or scale out eHealth-facilitated integrated care models.