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Comparison of Two Different Semiquantitative Urinary Dipstick Tests with Albumin-to-Creatinine Ratio for Screening and Classification of Albuminuria According to KDIGO. A Diagnostic Test Study

Hodel, Nikolai C. and Hamad, Ali and Reither, Klaus and Kasella, Irene Mndala and Abdulla, Salim and Schoetzau, Andreas and Hatz, Christoph F. R. and Mayr, Michael. (2021) Comparison of Two Different Semiquantitative Urinary Dipstick Tests with Albumin-to-Creatinine Ratio for Screening and Classification of Albuminuria According to KDIGO. A Diagnostic Test Study. Diagnostics, 11 (1). p. 81.

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Abstract

Semiquantitative dipstick tests are utilized for albuminuria screening.; In a prospective cross-sectional survey, we analyzed the diagnostic test validity of the semiquantitative colorimetric indicator-dye-based Combur9-Test; ®; and the albumin-specific immunochromatographic assay Micral-Test; ®; for the detection of albuminuria, the distribution of the semiquantitative measurements within the albuminuria stages according to KDIGO, and the utility for albuminuria screening compared with an albumin-to-creatinine ratio (ACR) in a walk-in population.; In 970 subjects, albuminuria (≥30 mg/g) was detected in 12.7% (95% CI 85.6-96.3%) with the ACR. Sensitivity was 82.9% (95% CI 75.1-89.1%) and 91.9% (95% CI 88.7-96.9%) and specificity 71.5% (95% CI 68.4-74.6%) and 17.5% (95% CI 15.0-20.2%) for the Combur9-Test; ®; and Micral-Test; ®; , respectively. Correct classification to KDIGO albuminuria stages A2/A3 with the Combur9-Test; ®; was 15.4%, 51.4%, and 87.9% at cut-offs of 30, 100, and ≥300 mg/dL, and with the Micral-Test; ®; it was 1.8%, 10.5%, and 53.6% at cut-offs of 2, 5, and 10 mg/dL, respectively. Overall, disagreement to KDIGO albuminuria was seen in 27% and 73% with the Combur9-Test; ®; and Micral-Test; ®; , respectively. From the total population, 62.5% and 15.3% were correctly ruled out and 2.2% and 1% were missed as false-negatives by the Combur9-Test; ®; and Micral-Test; ®; , respectively.; Compared to the Combur9-Test; ®; , the utility of the Micral-Test; ®; is limited, because the fraction of correctly ruled out patients is small and a large proportion with a positive Micral-Test; ®; require a subsequent ACR conformation test.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB
UniBasel Contributors:Mayr, Michael
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
e-ISSN:2075-4418
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:17 Mar 2021 11:36
Deposited On:17 Mar 2021 11:36

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